mdevere

This is very, very weak.

Clinical science is inundated with well-reasoned "potential leads". Ideas for targets, and even designing drugs to interact with those targets in the desired way, is not the bottleneck. Hasn't been for decades. The bottleneck is in clinical development i.e. human trials.

There are many many AI drug discovery companies out there, many of them very well funded, and ALL of them with no shortage of "potential leads".

These companies usually start out with the idea that their potential leads are better than the alternatives (generally because they cast a much bigger net/ considered more screening criteria than a human could, thanks to AI) and that big pharma will pay them license fees.

And yet, all of those companies, pretty much without exception, have turned into drug development companies themselves. They are forced to develop their own "potential leads" into actual approved drugs. And they are subject to the same timelines, same costs and - so far - the same probabilities of success as any other drug developer.

PerturbAI & OpenAI's "potential leads" might be better or worse than the next AI company. I would guess worse, given there is zero proprietary data involved and no clarity about why the underlying models are going to generate insightful findings. Either way, not useful.

PHOTOS

Glad to see that Shared Albums are now full resolution!

Now, please:

1. Allow us to edit the photo order of the Shared Album (instead of the order that the photos were added to it). Currently, my wedding unfolds in the wrong order, and my kid turns 6 months old before being born.

2. Fix identification/clean-up of duplicates.

3. Give us a way to tidy up facial recognition.

4. Allow us to join "best quality possible" collectives, which will replace our poor-quality photos with higher-quality originals from somebody else's library.

If this is true, I'll need to stop using Backblaze. I have been relying on them for years. If I had discovered this mid-restore, I think I would have lost my mind.

Very strange how HN elevates news about random drug candidates at very early stages of development.

There is a very active landscape of people developing/validating 'biomarkers' for neurological and psychiatric disorders and developing drugs specifically for those populations with the biomarker present; this news is far from extraordinary.

The real news is when these reach FDA approval.

Big fan of Bitwarden, albeit you are putting a single point of failure on all of your secure info.

I'd love to know what others do to maximise both convenience and security.

For two-factor authentication, I wouldn't use the same service for both layers. Seems daft to use Bitwarden as both the password keeper and the TOTP provider. Not sure if that's a cryptographically coherent view, but hey.

Every day I have to use something like 4gb of data to let Backblaze sync. This is despite the fact that I might only have created/changed 100mb worth of files since the previous day's sync.

He is out of his mind

How can you be the real Satoshi when _I_ am the real Satoshi? This guy is a fraud, don't listen to him!

Can someone explain to me how open source products can generate revenues like this?

Only 16m more to go

I don't have pics anywhere. That's all in Photos app/ iCloud. It's very cheap, something like $1 per month.

I use Backblaze to backup everything to cloud.

Generally agree with ppl who say that searching is more important than organising. I use Alfred to search, but I think the default Finder app is quite good these days.

Most important thing is having a consistent filenaming convention. This helps you find files via search. I use 'YYMMDD_HHMM name' if I authored the file or 'YYMMDD_HHMM [sender] name' if someone emailed it to me.

Tangentially, what I'm really happy with is how I manage my web bookmarks. I don't use browser bookmarks or folders. I save bookmarks to Pinboard.in, a cloud service. Then there's a nice Alfred extension which allows me to find them (http://www.packal.org/workflow/alfred-pinboard).

This is not a problem

i really like the idea but it's too expensive for me. i would consider this it if was $200 didn't have a subscription fee.

great guy

Why is this flagged?

i am certain the ppl who write these articles have also read the other 427 articles saying the same thing

any thoughts on SME customers vs consumers?

write a follow-up. it's interesting

the gifs are funny. hacker news is just a bunch of anoraks.

the most hacker news comment ever

How did you enjoy Vue vs React?

So this is like Medium but with monetised upvotes? Who would pay for upvotes? (and in particular, for a subscription)

excellent thank you

Some feedback

Preface: offline, I've heard good things about working at Stripe. So the following is intended as constructive.

The 'values' read more like a description of what the owners of any high-performance company would want out of their employees, transactionally-speaking. It reads much less like Stripe has a strong cultural identity. Reading this, it sort of feels like you are asking for a lot of my commitment to the Stripe mission without giving me any reason to buy into it.

I'm not sure there is anything idiosyncratic about this list. It doesn't really convey to me what it's really like to "be a Stripe" as opposed to "being a Googler".

Oh, and this phrase, "being a Stripe", it is the very worst kind of SV affectation. Maybe it works for people who are already at Stripe and proud to be there, but from the outside in, honestly it sends me cringing into the next universe. I don't think you have to be an enormous cynic to have that reaction to it.

Overall this seems to fail the test it sets itself: it doesn't convince me that the top team at Stripe are striving to building the best imaginable place to work, which surely is the best part about building your own company.

Hey, this sounds really interesting and I'd like to play around with it. However, I'm a novice and run into the following issue:

>>> examples.sales

<DataNode>

No idea what a DataNode is so am struggling to actually see the data! Any tips?