News for hackers. Stuff that matters.

logannyeMD

logannyeMD on Hacker News

Re:AMA: I'm Eric Ries (The Lean Startup) & Author of New Bestseller In... on Wednesday June 10, 2026 @02:32PM (#48480663)
No question, really - just wanted to say thanks for evangelizing this topic. I'm originally a medical doctor who converted to the ways of computer science, now a founder in the bio space. One thing I've consistently wrestled with is how to structurally defend our company's ability to "first, do no harm." I think the misguided incentives you raise warning about are also the primary reason for the defects we see in our (American) healthcare system today, particularly with the grievances toward big pharma and the insurance industry. So I was pumped watching your interview with Garry a few weeks back, currently working on applying it to our own little lemonade stand.
Re:Rosalind: A genomics toolkit in Rust running whole-genome pipelines... on Tuesday May 26, 2026 @05:48PM (#48286462)
Hey guys, this is my github repo. Glad it's received some interest - I figured HN might be the culprit when it suddenly jumped ~100 stars despite not working on the code base since last year. I prototyped this out of personal curiosity last year and moved on abruptly so there's a lot of gaps I still need to close and knobs that need to be optimized. But if people genuinely find "deterministic genomics workloads on edge devices" proposal useful, I'll begin refining the code tonight and try to make it as useful as possible. If you have any particular bioinformatics tasks or use cases that you want to be feasible on edge devices, lmk and I'll work on integrating new capabilities. Always happy to be helpful
Re:Colon cancer now leading cause of cancer deaths under 50 in US on Thursday March 12, 2026 @01:18PM (#47354161)
I'll echo this by saying that, as someone who has their MD, there is much we simply do not know. We're always updating our priors and have much to base our decisions off of, but we simply do not understand many things. Medicine is out here winging it with the best of intentions, but there are no "experts" in the grand scheme of things.
Re:There is No Quintic Formula [video] on Sunday November 30, 2025 @03:47PM (#46100260)
2swap makes some fantastic videos, I'd recommend giving them a follow on YT if you enjoy math visualizations. They also seem to spend quite a bit of time on the audio for each upload

Show HN: I made an open-source Rust program for memory-efficient genomics

Posted by logannyeMD on Wednesday November 12, 2025 @09:56PM
from the show-hn dept.

https://github.com/logannye/rosalind

My cofounder and I run a startup in oncology, where we handle cancer genomics data. It occurred to me that, thanks to a recent complexity theory result, there's a clever way to run bioinformatics algorithms using far less RAM. I built this Rust engine for running whole-genome workloads in under 100MB of RAM. Runtime is a little longer as a result - O(TlogT) instead of O(T). But it should enable...

( Read More... | no comments | 2 points | on HN )

Show HN: An ETL engine with hard memory guarantees

Posted by logannyeMD on Tuesday November 04, 2025 @06:25PM
from the show-hn dept.

https://github.com/logannye/emsqrt

This is an external-memory ETL engine that enforces hard memory bounds (as opposed to systems that can only try to stay within limits). It's the result of playing around with a recent idea from complexity theory, tinkering to find practical applications of where efficient time-space simulation could be useful.It enforces a strict memory cap via RAII tracking and scheduling, so you can process...

( Read More... | no comments | 2 points | on HN )
Re:I built a Texas Hold 'Em practice app after sucking at it during SF... on Monday October 20, 2025 @01:13PM (#45646400)
I recently went to a poker night during SF tech week and realized I'm not good at Texas Hold 'em. I wanted a way to improve that doesn't require me losing $100-200 every week, so I built this to get better between weekly poker nights. UI/UX is still very early, so any feedback that helps me make it more useful/delightful are appreciated. If you're in SF, hope to see you at one of the (many) weekly poker nights around the bay!
Re:Ask HN: What Are You Working On? (October 2025) on Monday October 13, 2025 @07:13PM (#45574328)
good idea, will add some this weekend
Re:Ask HN: What Are You Working On? (October 2025) on Sunday October 12, 2025 @09:54PM (#45563958)
Fwiw: the website is brand new and very much in the "hot garbage" phase of development. I'm not a front-end guy, so critique is welcome from all - especially any bugs in the UX. I'm still actively uncovering them
Re:Ask HN: What Are You Working On? (October 2025) on Sunday October 12, 2025 @08:06PM (#45563294)
Currently working on https://tinyZKP.com

It's an API that allows zero-knowledge proofs to be generated in a streaming fashion, meaning ZKPs that use way less RAM than normal.

The goal is to let people create ZKPs of any size on any device. ZKPs are very cool but have struggled to gain adoption due to the memory requirements. You usually need to pay for specialized hardware or massive server costs. Hoping to help fix the problem for devs

Re:LoRA Without Regret on Friday October 03, 2025 @06:56PM (#45468762)
Missed opportunity to title this "Lo-RAgrets"
Re:The Beginner's Textbook for Homomorphic Encryption on Monday September 22, 2025 @09:14PM (#45341723)
FWIW: I created a github repo for compact zero-knowledge proofs that could be useful for privacy-preserving ML models of reasonable size (https://github.com/logannye/space-efficient-zero-knowledge-p...). Unfortunately, FHE's computational overhead is still prohibitive for running ML workloads except on very small models. Hoping to help make ZKML a little more practical.