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kesavvaranasi

Ask HN: What tools do you use for computational biology?

I'm looking to learn about computational tools for computational biology and synthetic biology workflows. I see that many people use Colab notebooks for running protein structure prediction models (Alphafold, ESMFold, etc) and even generative design models (RFDiffusion). But these notebooks time out frequently.There are also "Cloud labs", which let you outsource laboratory work. I'm interested...

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I've been using ChatGPT to get a crash-course in Next.Js. I'm coming from a backend and data eng. background so ChatGPT is helpful for getting advice for modifying Next.JS components for the project I'm working on. Similarly, it's been helpful for styling SwiftUI views for iOS app dev.
My taste in games changed...as a kid my favorites were Assassin's Creed and Call of Duty. Today I play games like Crusader Kings 3 and Kerbal Space Program. There aren't any single-player console games that I find that great, other than Spiderman for Playstation.
I subscribed only because I wanted to create a custom GPT.
Re:TechBio Adventures on Friday February 16, 2024 @10:37AM (#39398421)
My article discussing my learnings in TechBio.
Commenting because I'm curious about what you mentioned about getting your B2B subscribers through your newsletter. Seems like a cool way to get inbound. I started my own newsletter recently and I'm hoping to follow a similar strategy to you for getting customers.
My workflow is typical: create a feature branch from main/master, raise a PR when ticket is complete, and maintain a separate release branch for production deployments. I use rebase instead of merge so the commit history doesn't get cluttered with merge commits.

Pain points: -coming up with good commit messages -including the story ticket number in the branch name and commit message

Re:Ask HN: How to Learn Cloud Development? on Monday February 12, 2024 @12:04PM (#39347313)
What helped me when I started 4 years ago was taking some certification exams offered by AWS and Azure. They're a bit pricey in my opinion but I needed a structured curriculum to guide my learning.

Other than taking these exams, I just set up an AWS account and played around with the services, which is free if you stay within the usage limits of the free tier. I started with learning about the core services, how to provision infra using infrastructure-as-code, how the billing model works, etc.

Check out replit. They implement a browser-based IDE. I could be mistaken, but I don't think it's really focused on tutorials/teaching.

What comes to mind immediately is how to use the tooling that usually comes with an IDE. If you could add tutorial on using the debugger and git tooling that comes with popular IDE's like VSCode, I think that would be helpful for people looking to make the jump from coding on the side to doing it professionally.

I like the idea of a course centered around a guided project. For example, learning Swift by developing a simple iOS app.

Maybe I'm missing something, but why does the platform need to be a desktop app?

How I created my own AI assistant to help me prepare my favorite Indian recipes.
Re:Ask HN: Good Books on Philosophy of Engineering on Friday January 19, 2024 @01:20PM (#39059054)
For software engineering, I recommend A Philosophy of Software Design. It has principles that I think translate well to other engineering fields.

For engineering in general: To Engineer is Human - Henry Petroski The Art of Doing Science and Engineering - Richard Hamming Structures: Or Why Things Don't Fall Down - J.E. Gordon

Re:Ask HN: How often do your review notes? on Wednesday January 17, 2024 @03:20PM (#39032891)
I find the act of writing down a note to be more useful than the note itself. It helps me commit something to memory. I use mini yellow legal pads for jotting down interesting ideas I come across. Maybe once a month I'll pick up a pad that I've filled with notes and skim through.
Re:Ask HN: What is a good lecture series on physics? on Wednesday January 17, 2024 @01:37PM (#39031612)
Leonard Susskind's The Theoretical Minimum is a favorite of mine. There's a series of lectures on Youtube that accompanies the books.

Check out L.D. Landau's Course of Theoretical Physics if you're open to reading a textbook.

I don't understand why Apple is asking for a commission if the developer is implementing their own payment flow. If Apple is still mandating that you offer in-app purchase as an option alongside a custom payment flow, then Apple charging a commission for both options seems excessive.