ivanech

Mosaic trisomy, where only a subset of cells have extra chromosomes, is possible for essentially any chromosome including 21.

This makes some trisomies survivable, e.g., trisomy 16 which is otherwise incompatible with live birth.

Yes you can drive up to your opponent and hit them point blank

Wow, that’s an egregious chart crime. Surely there’s a way to make a chart that isn’t so dishonest. Just plotting the SPR level would make the same point honestly.

Hmm in my experience (I've done a lot of head-to-heads), Opus 4.6 is a weaker reviewer than GPT 5.4 xhigh. 5.4 xhigh gives very deep, very high-signal reviews and catches serious bugs much more reliably. I think it's possible you're observing Opus 4.6's higher baseline acceptance rate instead of GPT 5.4's higher implementation quality bar.

This feels similar to March 2020 when COVID was in Seattle. “It’s in the US but maybe it’s just a one-off.” We’ll see, I guess.

this was really delightful. The Easter eggs in particular made it feel like someone was actually on the other side

I find Opus 4.5 very, very strong at matching the prevailing conventions/idioms/abstractions in a large, established codebase. But I guess I'm quite sensitive to this kind of thing so I explicitly ask Opus 4.5 to read adjacent code which is perhaps why it does it so well. All it takes is a sentence or two, though.

I believe the new grad DOGE employees were GS-15s. So yes, it seems likely that they plan to hire at GS-14 or GS-15.

tried replicating w/ a slightly different system prompt w/ sonnet-4.5 and got some different results, esp w/ progressive to conservative questions. Prompting seems pretty load-bearing here

AI tools have been so good for me for making home-cooked software. As a new-ish parent, it’s so much easier to do stuff. I don’t need to go into extra-deep focus mode to learn how to center a div for the hundredth time, I can spend that precious focus time on the problems that matter / the core motivation.

I had a good laugh at the image showing that 2018 had a “quality focus”

I think Jonathan Blow gave his “Preventing the Collapse of Civilization” talk (much stronger treatment of the subject matter) around that time, also about how software quality was only going down

> Gold has reached all time highs

this is true

> US debt (ie T-bills) selling at all time lows

this is not true unless you’re doing some kind of adjustment. For t bills, us03m yields were much higher 30-40 years ago.

> US equities are at all time highs

this is true

> USD falling day over day, month over month, year over year

if falling means inflation, yes in banal way. If falling means relative to other currencies, that’s the last 9 months or so. Previously the USD was quite strong

> US debt is falling in value because no one wants to buy it

this appears to be the hinge of the argument? It is not true. 10y yields have been down / flat since beginning of 2025 (i.e., price up). also tsy auctions remain well-subscribed / within historical range

I would not debase myself by causing the starvation of children.

Just got it at work today and it’s a dramatic step change beyond Cursor despite using the same foundation models. Very surprising! There was a task a month ago where AI assistance was a big net negative. Did the same thing today w/ Claude Code in 20ish minutes. And for <$10 in API usage!

Much less context babysitting too. Claude code is really good at finding the things it needs and adding them to its context. I find Cursor’s agent mode ceases to be useful at a task time horizon of 3-5 minutes but Claude Code can chug away for 10+ minutes and make meaningful progress without getting stuck in loops.

Again, all very surprising given that I use sonnet 4 w/ cursor + sometimes Gemini 2.5 pro. Claude Code is just so good with tools and not getting stuck.

Amrstrong’s heart rate spiked to >150bpm during the moon landing, more than double his resting heart rate

Thank you, Dan! I really appreciate all the work you do making HN what it is

“Redfin data shows millennials are more or less on track with previous generations”

“more or less” is doing some heavy lifting. The chart referenced shows a pretty dramatic discontinuity between Millennials and Gen X / Boomers from age 25 to 35 w.r.t homeownership rate.

Click the links for “Available” and “Employment” at the bottom — they link to what I assume are the roles he’s looking for

Ha! I was thinking of Google specifically. I imagine it varies significantly then. Maybe 40+ L5 is not an OOM more common than 7, but L5 + L6 I think safely is. Agreed on L7 pay, very doable.