davecap1
Re:Weak-to-Strong Generalization
on Thursday December 14, 2023 @02:42PM (#38646236)
There's a lot more to protein sequences than legos. I think the argument is that you don't need to train a model on fundamental organic chemistry/biochemistry, electrostatic protein interaction, hydrogen bonding, hydrophobic interaction, quantum mechanics, etc... in order for it to accurately predict protein sequences.
Re:AWS us-east-1 outage
on Tuesday December 07, 2021 @11:23AM (#29474356)
We have federated login with MFA required (which was failing). It just started working again.
Scratch that... console is not loading at all now :)
Re:AWS us-east-1 outage
on Tuesday December 07, 2021 @10:51AM (#29473786)
On top of that, the "Personalized Health Dashboard" doesn't work because I can't seem to log in to the console.
Re:Launch HN: Seed (YC W21) – A Fully-Managed CI/CD Pipeline for Serve...
on Tuesday January 19, 2021 @03:38PM (#25838572)
How does this compare to something like AWS CodePipeline with CDK (https://docs.aws.amazon.com/cdk/latest/guide/cdk_pipeline.ht...)?
Re:This month in 1939: How dead cattle led to the discovery of warfarin
on Monday July 27, 2020 @09:15AM (#23964744)
It's been 80 years and we still haven't figured out how to reliably perform loading doses (when someone is just starting out on warfarin) and to maintain stable INR (anticoagulation effectiveness, essentially) in people who take it daily. Lots of work has been done on it, but it is petering out due to the recent introduction of new anticoagulation drugs that do not require regular monitoring.
I happen to take warfarin daily, happy to answer any questions!
Re:Invert, always, invert
on Tuesday July 21, 2020 @07:00AM (#23905883)
Interesting way of describing/thinking about hazard or risk analysis which is applied in many industries through ISO standard frameworks such as ISO 14971 for medical devices (but is also used elsewhere). Risk analysis complements requirements analysis in that risk mitigation plans become requirements of the system (if the risks meet some threshold).
Re:Local-first software: you own your data, in spite of the cloud
on Wednesday November 20, 2019 @11:59AM (#21585687)
Apple Health and Activity also seem to work this way, although they also sync to iCloud.
Re:Decentralized VPN Written in Go
on Tuesday November 12, 2019 @08:27PM (#21520288)
Is this similar to ZeroTier https://www.zerotier.com/?
Re:Ask HN: How do you make sure your servers are up as a single founder?
on Wednesday November 06, 2019 @09:14AM (#21462751)
Have you thought about hiring someone remote in the same or different timezone to be on-call for outages? I'm sure there are many people around that would be able to help with this. You could hire someone on a retainer who can be on-call via PagerDuty or something.
Re:DNA sequencing progress has stagnated
on Tuesday July 30, 2019 @01:24PM (#20566999)
23andMe only tests for known relatively common mutations (single nucleotide polymorphisms, or SNPs) that have been identified by non-profit large scale sequencing projects done in the past (basically public data now, see dbSNP for instance). You will almost certainly have mutations that are not covered by their panel, so it is not a matter of comparing your 23andMe results to the "baseline" (or "reference genome"). Their panel costs in the hundreds of dollars to run since it is so focused (at least 10x less than a full "exome" test, which would look at the full sequence of all known genes).
Re:How to Grow Software Architecture out of Jupyter Notebooks
on Wednesday December 12, 2018 @06:18AM (#18662941)
Is this similar to papermill?
Re:11-year-old girl inspired by Flint water crisis creates cheap kit t...
on Monday October 23, 2017 @05:39PM (#15537153)
If you are in NYC you can test your water for free: http://www1.nyc.gov/nyc-resources/service/1266/request-lead-...
Re:What if we made video conferencing work?
on Tuesday May 02, 2017 @07:44AM (#14245564)
There are a bunch of options for low-latency video conferencing solutions available for people who actually need it (tele-medicine/surgery, sports/media broadcasting, enterprise conferencing). The thing is they just cost a lot of money and require dedicated hardware. Here's one company I know of that does this: http://www.haivision.com/
Re:Ask HN: What medical datasets do you need?
on Tuesday April 04, 2017 @09:04PM (#14038800)
These are quite difficult to get (and very expensive to produce) even inside the medical-research establishment. Which big players are you referring to?
Re:Nylas Mail is now free
on Tuesday January 17, 2017 @11:36AM (#13418874)
There are other mail clients that use tracking pixels, like Polymail and Canary.
Re:Mermaid: Generate Diagrams and Flowcharts with Markdown Like Syntax
on Thursday January 05, 2017 @09:35AM (#13327349)
draw.io is awesome! Thanks for the hard work!
Re:AWS CodeBuild – Build and test code with continuous scaling
on Thursday December 01, 2016 @12:43PM (#13081489)
This sounds a bit like BuildKite which has worked out pretty well for us! They provide an elastic AWS CI environment that you run in your own AWS account, and scales up/down as builds are queued up.
Re:Announcing pydoc.io beta
on Sunday November 20, 2016 @11:42AM (#12999671)
Just FYI `https://pydoc.io/` doesn't load but www.pydoc.io does (at least for me).
Re:Ask HN: Do you have a side project you want to sell?
on Monday November 07, 2016 @04:19PM (#12895224)
We recently changed the permission to introduce the "pro" blocking feature. There doesn't seem to be a way to get "write" perms in a more granular way. The app doesn't actually post anything though.
Re:Ask HN: Do you have a side project you want to sell?
on Monday November 07, 2016 @02:56PM (#12894419)
https://www.twitteraudit.com
Estimates fake Twitter followers for any account. Helps users find and block fake followers (coming soon). >100k visitors per month (45% returning). >1M users audited and over 500k users signed-up. Some revenue ($12k/year).
Re:Poll on macOS 10.12 is broken
on Tuesday October 11, 2016 @09:43AM (#12684270)
I run linux on the desktop and 1password actually works surprisingly well via Wine. Even the Chrome extension seems to work.
Re:Stencila – Spreadsheet-like live reactive programming environment
on Thursday March 24, 2016 @10:05PM (#11358042)
Off-topic: how do people make those animated gifs like the one in the blog post (https://stenci.la/stencila/blog/introducing-sheets/screencas...)?
Re:Ask HN: Who is hiring? (February 2016)
on Monday February 01, 2016 @01:01PM (#11013664)
SolveBio | New York City | Full-time (ONSITE)
SolveBio provides a data platform and data science services that can deployed in genomics companies - large pharmaceuticals, R&D labs, molecular diagnostic companies, and health startups. The platform and APIs process and deliver a wide variety of complex biomedical datasets collected from public, private, and commercial sources creating a solid foundation of information necessary to develop more accurate genetic tests for diagnostics and discovery. SolveBio has great backers including Andreessen Horowitz, Max Levchin/HVF, Healthy Ventures, Great Oaks, Red Swan, and others.
We're looking for engineers to further develop our genomic data platform, which includes APIs that feed up-to-date information to customized interfaces, internal data pipeline tools, and secure multi-datacenter deployments. Genetic testing is entirely dependent on reference data and as the industry continues to grow at a rapid pace, SolveBio aims to be a leader in this very exciting space.
Tech stack: Python/Django, JS/AngularJS, ElasticSearch, PostgreSQL, Docker, AWS, Consul, Terraform.
Interested? Email us at: [email protected]
Re:List of high-quality open datasets in public domains
on Saturday January 30, 2016 @10:22PM (#11005084)
SolveBio (my startup) has parsed, normalized, and indexed a bunch of the datasets listed under biology. Our goal is to make these kinds of datasets easier to access for programmers and non-programmers alike, similar to other some sites mentioned here (Enigma and Quandl) but for genomics. You can query and filter the data on the website or through one of our API clients: https://www.solvebio.com/library
Re:How to Fix Everything: Spending a few days at iFixit
on Monday November 30, 2015 @09:09PM (#10653260)
You can do that today... it's not the only way but I'd imagine it's pretty common: http://www.apple.com/shop/iphone/iphone-upgrade-program
Re:Why Rdio died
on Wednesday November 18, 2015 @07:44AM (#10587349)
If Spotify becomes its own "label" then it'll probably have a better chance... given the size of its user-base.
Re:Fame for sale: efficient detection of fake Twitter followers
on Sunday October 04, 2015 @01:35PM (#10328131)
You can try twitteraudit.com (I made it a few years ago). It doesn't do anything fancy at all, but it works pretty well with about a 10% margin of error. It only looks at a sample of 5000 followers though.
Re:IBM's Watson will be used to make decisions about cancer care in 14...
on Wednesday May 06, 2015 @06:51PM (#9502282)
Cancer is a disease of genetics. You need to know what kind of cancer someone has in order to choose the treatment.
Re:Input, a flexible font for programming
on Sunday March 22, 2015 @10:35PM (#9249212)
It actually comes with a monospaced variant.