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atrexler

right
I've no idea about the fasting stuff. Just thought its important to make clear this particular study is all about doing stuff to cells or lumps of cells in dishes (again sorry if I missed more involved model system in the paper). Whether thats a good model for cancer in people and how fasting interacts with that I honestly have no idea.
Well, to be precise- this study shows no evidence of a fasting effect.

they show if you starve cells in a dish in a way that might mimic what happens when you fast, you can kill the cells. I didn't see any mention of even mouse studies in there, so I don't know what their in vivo model was but it mostly looks like cell culture to me (apologies if I've missed that). Extrapolating that to humans is extremely hard.

For sure a promising result but its pretty preliminary.

this isn't how chemotherapy works. traditional chemo targets rapidly dividing cells in the body: cancer, hair/skin, intestinal lining cells. That's why you get those side-effects.
Re:The rescue of the crew of the yacht Django (2016) on Thursday July 12, 2018 @11:55AM (#17515801)
+1! New go-to for suggesting there's evidence you're about to have a bad time.
Overload your gels much bro?

JK- just looking for those impurities.

"Who's more foolish, the fool or the fool who follows him?"
Re:Sci Hub repository torrents of scientific papers on Monday May 21, 2018 @11:50AM (#17119255)
https://www.ascb.org/newsletter/novemberdecember-2016-newsle...

"This money is effectively a surcharge, or tax, on scientific research imposed not by a government but by a for-profit industry. Imagine for a moment how much research could be carried out using these resources if they were channeled back into our academic enterprise."

I wonder at how this would vary across industries and also company sizes. I'm surprised the study had positive results at a relatively large firm. I think its easy to imagine working-from-home gains in small firms and startups where typically there's a much stronger selection for highly motivated and enthusiastic people. It's not clear the same would result in a huge firm where you have less of that selection.

Also how does one measure productivity? (this is probably a naive question as a relative neophyte) An article I found on this says they were 13.5% "more efficient" but I'd love to get the details on what that means. Its a travel agency so are they just booking, scheduling, organizing, etc? Would love to see a similar study in a SW dev environment, alternately something less tech focused but collaborative...I dunno but something creative most likely.

Re:Taskwarrior, where have you been all my life? on Wednesday May 09, 2018 @06:02PM (#17034573)
I'm currently using Asana for task management. I guess the only upside is that I can share tasks with my wife, but its clearly not really meant for just single person management.

Has anyone tried both taskwarrior and asana? Any obvious pros/cons?

taskwarrior seems much simpler and can live locally if you dont want locked in asana/whatever?

Re:Ask HN: Anyone making money through algorithmic trading? on Wednesday April 25, 2018 @04:01PM (#16925474)
beware survivor bias on this thread.
Re:How Many Genes Do Cells Need? Maybe Almost All of Them on Monday April 23, 2018 @04:21PM (#16907035)
The proteins that organize DNA, called histones, can be chemically modified in a variety of ways. The modifications have the effect of turning on/off stretches of the DNA simply by modifying its physical structure (the way the dna is arranged and packed around the histones). There are tons more mods that can happen which have a variety of effects (for example, tune the amount that a gene is expressed). This is called epigenetics if you want to google more.

If you've heard of those studies where if your grandparents experienced a famine it makes some difference in your genetics, one hypothesis is that its caused by this.

Absolutely agree with your point. I don't think the practice in any industry (trucking, healthcare or distribution centers) is okay but I'm simply pointing out its not a unique problem.
Sure, I can't tell you about white collar folks pissing in bottles, I may have exaggerated there.

But in healthcare (for nurses, therapists, aides) its quite prevalent that people don't drink/eat enough at work nor do they take proscribed breaks because productivity standards are so high.

Look I'm not saying its right or fair or good. I'm simply pointing out that its not unique to Amazon.

Long-haul truckers have been doing this for decades for the same reason-- they don't have time to pull over and use the restroom-- and no one is upset about that. I'm sure there are many industries, white and blue collar, where similar norms are expressed.

Edit to add: I'm not endorsing the practice in any industry at all, just pointing out that its not a unique problem to Amazon. My comment would have been better phrased "why aren't more people upset about that?" It IS still definitely a problem!

Re:The Artificial Intelligentsia on Sunday April 15, 2018 @03:10PM (#16844317)
Outside of the firms owned/operated by the real clever boys, I wouldn't be surprised if this describes the vast majority of "AI" efforts unfolding at dozens/hundreds/thousands of companies. Everybody is getting on the bandwagon and either don't have any clue or find out that their customers don't even want what they are selling at the end of the day.

I'd be shocked if anyone in the industry hasn't worked for or with a Jim. Spot-on.

Re:Is AI Riding a One-Trick Pony? on Saturday September 30, 2017 @08:22AM (#15372537)
The thing you have to figure out, is that our brains and consciousness are just a big collection of "thoughtless fuzzy pattern recognizers". There's nothing magic beyond that.