arboghast

That's what I mean yes. English isn't my first language. How should I have phrased it?

It's not a meme. If you look at research that look at foods rich in micronutrients, you'll see that meat covers most of them.

For example, yes Kale is rich in calcium and vitamin K than meat in general, but beef, pork or chicken covers a higher ratio of micronutrients than Kale. Obviously, one should not only eat meat. But the point was that meat itself does not make you sick (unless in excess, like anything).

> Similarly, plants and plant-based foods have full amino profiles. Once again, plug anything from soy beans or even broccoli into Cronometer.com and look at the amino acid breakdown.

Full amino acid profile doesn't mean that it contains the same amount, it just means that it's present. Moreover, nutrient absorption is often lower with vegetables than with meat.

Again, not saying one should not eat vegetables. One definitely should eat fruits and vegetables. But it's clear that lacking meat in one diet has long term consequences that reveals itself later in life.

It isn’t, in fact it’s more nutrient dense per calories than vegetables and legumes and rich in amino-acids necessary to maintain muscle mass which is increasingly important as you age.

It’s just something the anti-meat crowd parade, while omitting that:

- These beliefs come from epidemiological studies without regards for other life habits such as smoking or dietary choices such as sugar intake.

- Often when saying meat is bad, what is actually referred to is processed meat packed with salt and nitrites.

Eating chicken, pork or beef that you buy raw and cook yourself is healthy.

How much you eat of anything matters too. Don’t eat anything in excess and move.

It’s going to be 12c today so it’s not that bad. The 1998 one was in February so it was very different.

I don’t disagree and it’s purely anecdotal.

Here’s the thing, I don’t work out much, if at all other than cleaning the house and mowing the lawn. Not much has changed on the lifestyle side, overall.

I recently started doing the stepper and noticed the improvement compared to occasional physical activity that I inconsistently do from time to time (e.g. sports outside with the kids).

Edit: typos

I started taking 3g of pharmaceutical grade fish oil about 1 year ago with 5000IUs vitamin D and 120mcg of K2 MK-7. I don’t “feel” anything but my Garmin is clear that my RHR and VO2max have greatly improved, and yet that’s on 5-6h sleep per night. I’m also definitely less sick.

Now question remains, which of those is responsible for this?

Never heard of that. References?

Either way, I agree that IF is the best inhibitor of mTOR. My guess is that there is much we don’t know still about the effects of Rapamycin and mTOR itself. Clearly mTOR inhibition extends lifespan considerably in mammals, but we also know that protein intake is crucial to retain muscle mass in old age. Seems like a double edged sword. Question is, using rapamycin, can you still consume adequate protein amounts and retain muscle mass?

While I agree with most of the critics towards the article and the author (who by the way, is a friend of Peter Diamandis who also happens to run a scammy longevity clinic), (some) reasons behind the longevity of many of those centenarians have been identified: low mTOR activity and high omega 3 intake. mTOR (mammalian target of rapamycin) is a nutrient sensing enzyme particularly sensitive to some amino acids like Leucine found in meat and whey protein.

Rapamycin (Sirolimus), an immunosuppressive drug was found to considerably inhibit mTOR activity. Past clinical trials recently showed considerable lifespan extension in multiple animal models and will likely work in humans. It’s one of the too drugs found in the ITP trials (1). If I’m not wrong, they are even starting trials now and new ones will come soon. That’s because, as the name implies, that enzyme is part of all mammals.

Lots of people experiment with safe dose ranging from 5 to 10mg once a week and report lots of benefits, few side effects (doses aren't as high as if used by organ transplant receivers).

I’m in my 30s so I’m not willing to take any risks with those. I move, I eat a Mediterranean-ish diet, take Vitamin D3, K2 and Omega 3d and eat no sugar. But if I was past 60 I’d definitely ask my doctor.

That being said, this is not radical life extension. That would likely be possible with upcoming therapies like partial reprogramming or senolytics. But it definitely is promising and will possibly help living a longer and healthier life if repurposed for other diseases than simply immunosuppression.

(1) https://www.nia.nih.gov/research/dab/interventions-testing-p...

Happens all the time and those threat feeds aggregation platform that have a black box ML confidence generator for IOCs aren’t trustworthy either.

In this day and age, if people don’t put emphasis on TTPs and still only rely on old style threat intel, they will become obsolete.

I’m sure he is. It’s easier for Scandinavian countries because they don’t have such a large, deserted territory. But most of the Canadian population is concentrated in specific areas, mostly in the southern part. There are some relatively large towns below the 55th parallel, but for the most part it’s large, empty land with small communities and reservations spreaded across the territory.

Starlink would provide broadband to communities that still don’t have it, or have it at a higher price because it’s a different satellite internet provider. Even more so past the 55th. I’m sure Santa would appreciate too.

I reached the same conclusion as you when I became a biology student and started to learn about morphogenesis, epigenetic reprogramming, DNA repair enzymes, etc.

I wouldn’t have said that a few years ago and would have accepted my fate. However, now my perspective has changed because we’re on the verge of a revolution in biotech (we’ll, one could argue we are in the middle) where we understand enough of the aging process - not all of it - to reverse it or at least slow it down.

However, I’m really disappointed with some of the people in the field such as David Sinclair who have become snake oil salesman and almost charlatans, pushing inconclusive science as facts (e.g. resveratrol, sirtuins, etc) and I think it hurts the field more than anything else.

Interesting years ahead, that’s for sure. I wouldn’t mind living a few more decades as long as I’m healthy and active.

You mean I can’t just telnet and send a power surge?

Except that in his podcast he spreads a lot of bad science. I'd even call it misinformation. The work on Sirtuins role in health span and life span is, at most, inconclusive. Multiple studies on trans-resveratrol failed to show any improvement whatsoever (and yes, even when mixed with a fat to increase bioavailability). Maybe NMN does something, maybe not. It's not yet clear.

He states everything as facts while most of his own studies have never been successfully replicated, even disproven in some cases.

I'd take everything he says with a grain of salt. He's been called out multiple times by his peers, including his own friends like Matt Kaeberlein.

Never had a sweet tooth to start with but I replace all sugar with monk fruit and erythritol blends like Lakanto (taste same as table sugar unlike Stevia).

Made a big difference already. Then I’ve cut all simple carbohydrates or non-soluble fiber and unlike the low carb craze, increased my high soluble fiber intake from low GI whole grains like steel cut oat. Keeps me full for a while, low calorie, and I don’t feel sluggish.

I don’t eat anything above 50 on the GI scale. Once a week I might have pasta.

No fruits because of fructose but lots of vegetables.

No drinks containing sugar like sweetened Almond drink but I keep the milk because the fat and the protein helps feeling satiated.

Basically I lost about 20 pounds over 3 months and I’ve maintained the loss for 2 years now.

If you don’t want to start in a junior position such as triaging, aim for things like detection engineering by learning OS internals (Windows or Linux), then also aim to learn the Win32 API. There are also lots of SOC and Blue Teams doing automation and orchestration where your existing skills could be handy.

Those are very valid points. I had not thought of them. However, what you describe here really is not the reality of our team but I agree it’s the case in most places.

I work for a large multi-national in the entertainment industry with a really good work culture. We leave a lot of autonomy (we in fact expect people to become autonomous) and trust that we all know how to do our job. It has been very rewarding so far.

On the technical side, very few of our positions are entry level, some are but most are more advanced.

For example, we reached a maturity level where we don’t only build detection but we also build unit tests for them, either by making our own payloads or use and contribute to projects like Atomic Red Team. This requires excellent knowledge of OS internals, cloud security, system programming, etc.

Your comment makes me think we should try to reflect all of this in the job description to make the positions more appealing. There might be good candidates out there hesitating, thinking it’ll be like life in an MSSP SOC.

Blue Team positions, junior or senior. There’s no shortage of decent penetration testers but when it comes to the other side, whether it’s incident response, detection engineering, security operations, etc it’s been very difficult.

I’m talking months to find someone. Many candidates apply and look good on paper but turn out to just lie and made us waste many hours of interviews.

As for the why, I suspect one of the following:

- good candidates already have a job they love

- people are not willing to relocate (job is remote but inside one of the countries we are operating in, which is 80)

- there is simply not enough people in the field, which goes back to my first point

That’s pretty clever. I like it.

Macros are less commonly used as an attack vector for initial access nowadays. Sure they’ll make it harder for macros, but still is possible to run a one-click attack by attaching a js, jse, hta, paf, ws, wsf, scr, etc. to an email.

Some of their engineers must really love books, and others really hate podcasts.

I had the same feeling about iCloud before I had a Mac and just a iPhone, but now that I have a Mac and that there are features such as “Sign-in with Apple” and “Hide My Email”, I can’t imagine living without. Apple Books is also a great eReader for PDFs and ePubs on macOS and iPad/iPhone which provides syncing across all devices. Not just the books themselves but also the chapters you’re at, bookmarks, notes, etc.

I suggest revisiting and if it’s not for you, that’s fine. But otherwise, yeah never sign-in with Apple.

At least they are not agressive about it, unlike Windows 10 or even 11 home which doesn’t even allow local accounts.

A bit of a tangent, but I'm not a big fan of Snaps (or Flatpaks for that matter). Whenever I tried to use them, I ran into issues as soon as I need to do some changes in the configuration.

Take Firefox on the latest Ubuntu for example, it installs as a Snap. Unlike the APT package (or any other package manager) version, the usual ~/.mozilla/ directory changed location. This broke some of my customization scripts and other people's scripts I'm using such as https://github.com/black7375/Firefox-UI-Fix

I would really, really, like if both Flatpaks and Snaps could keep the usual program's config directories. Then I would likely use them often because they have big advantages (especially Flatpaks) over package managers, especially for dependencies.

> But the subjects all lost weight even before they cut out carbs. Taubes contended that was because the standard diet didn’t have enough refined sugary beverages to depict average American consumption.

That explains it.

Doses used in the Mayo Clinic trial was about 1.5g to 2g for humans, 5 days per month, iirc. Also keep in mind that if you are young and healthy you won’t notice much and it’s the kind of treatment like most that are long-term, meaning you can’t do it 3 months and expect results.

There are many imminent aging therapies in clinical trials though or upcoming. Not saying it will reverse it but it may slow it down and compress the morbidity period. Such therapies include the promising Mayo Clinic trial on using large doses of Fisetin to get rid of senescent cells, or similarly Dasatnib + Quercetin, gene therapy like PGC-1a for maintaining muscle mass in older age, epigenetic reprogramming, mTOR inhibitors like Sirolimus or other rapalogues, etc.

So it’s very likely that some of the advances we see today that are still in clinical stage will hit the market in 5 to 15 years.

Edit: typo

Doesn’t allow you to create standalone binaries. Cython requires you to package the Python runtime DLLs (on Windows) otherwise it won’t run.