alakin

Fair and solid focus on government domain issues. It's us the people that will fix govt, instead of govt fixing companies.

Anti monopoly law already handles that.

And you're suggesting what, that we hand the reins to the democratic process you just described as flawed, one that is corrupted by lobbying? Yeah why don't we just take a corrupt institution and put it in charge of more things.

Are children and young adults banned from selecting products based on marketing inside stores?

Pretty much everywhere else they pretend to not have lobbying or bribing, but just end up doing it behind closed doors.

Employees should have capped liquidation prefs!

It's pretty interesting to think about happens from an economic perspective. Say I buy a house on loan (money withdrawn from capital markets). I hand cash to the previous owner and they use it to pay back their loan (return money back to the capital markets, keep the difference).

Consider the synchronous chain. Me: Myprofit=future_profit-cost1 Prev owner: profit=cost1-cost2 Prev owner 2: profit=cost2-cost3 And so on...

Also consider a parallel behavior where I can simultaneously buy and sell multiple properties though debt.

It would be fun to model this whole chain and understand what this recursively unfolding process actually does with capital. Is it a capital sync? What behavior does it incentivize? Does it guarantee expansion/recession cycles?

Your advice is somewhat dangerous if people follow it expecting them to magically work. First, the NASA study is for VOCs, not pm2.5. Second, when I briefly looked into using plants to clear VOCs indoors, I found that the number of plants, lights, and air-circulation required is completely impractical. Plants are awesome, I love them, but they're not enough. I wish it wasn't so.

My use case is pretty much parallel time series alignment with several layers of aggregation. I guess I perceive stream-stream joins as an easy way for me to wrap my head around how to structure my compute graph, but it seems doable with the method mentioned by @grammr. I'd hope for an interface roughly like "CREATE join_stream from (SELECT slow_str.key AS key, sum(slow_str.val, fast_str.val) AS val FROM slow_str, fast_str INNER JOIN ON slow_str.key = fast_str.key)". I do realize there are some tough design decisions for a system like this, but I'd also like to drop my wacky zmq infrastructure ;)

That's awesome! If you don't mind - one more q.. I see that stream-stream joins are not yet supported (http://docs.pipelinedb.com/joins.html#stream-stream-joins). Can you comment on when you think this feature cold land or is it still a ways off?

Is most of the intermediate processing done in memory, or is it limited by hd write speed?

Great, let's evaluate the deaths caused by regular cars. Lets evaluate risks posed by burning fossil fuels. Let's evaluate pretty much every single little detail about other auto brands and present our findings in a fashion where we can compare and rank best to worst. Having just done this I'm completely satisfied with Tesla's approach in comparison to what other brands have been doing.

As far as I'm aware the majority of failing biotech companies have very broadly targeted Amyloid beta (apparently because they thought it was a good risk tradeoff). A narrow focus on APOE4 could be a wiser strategy. I could even see gene therapy playing a role.

Sounds like a great time to start a biotech company. Though there will be some competition. Am aware of at least two companies in this space ;)

They used to have it visible, but it's been moved to an archived report. You can still find out from the raw data report here though: https://www.23andme.com/you/explorer/gene/?gene_name=APOE

If you are CC genotype for marker rs7412 AND marker rs429358 your status is APOE4.

Note that there are several other markers/genotypes that can reduce risk, but research appears to point to APOE4 status having the most impact. Also be aware that genetic reports could always have errors due to chance, operational errors, or problems with original research.

I get that you have strong feelings. But this is just uninformed. If you took a sec to understand Musk's comp structure you'd see that its paper wealth, as in he doesn't take cash out of the company. Instead he puts cash in the company. Also he only sold stock to pay taxes. I'd guess its likely he paid more in taxes than you, if you're an average earner.

Couldn't they just use multiple fibers per display to get around that problem?

because you could spend a tiny amount of effort/time to search for a newly available treatment to prevent the worst case scenario

There are a really large number of companies working on eliminating up stream causes of Alzheimer's, many with promising results. So early detection gives you time to find out if there is something you can do about it, to prepare for the eventuality, and to save a bit of money for treatment.

There is a genotype called ApoeE-e4/e4 which increases risk by 11x. https://snpedia.com/index.php/APOE

Interestingly the only differences between Apoe4 and a neutral, very common variant called ApoE3 is one amino acid at position 112. The small variance appears to account for most of the negative effect of the ApoE4 genotype. https://www.ncbi.nlm.nih.gov/pubmed/28533891

As I understand this only works for E3/E4 variants. Not homozygous E4/E4.

SEEKING WORK - San Francisco, remote ok (prefer local)

I'm a full-stack software engineer looking for ~20hrs/week of freelance work while bootstrapping my own company.

I enjoy building and launching products (have done that numerous times).

Core skills include:

- Building / Launching products

- Backend: Rails / Node

- Front end: React & react native for mobile. Angular.js

Especially interested in projects related to: - Deep learning / computer vision - AR - VR - Drones - Robotics - Healthcare / genomics / computational biology / bio research

Email: antonlakin at gmail

This is key.

Apoe status appears to control the absorption rates of LDL cholesterol (tiny balls of fat).

Individuals with apoe4, appear to have really low LDL cholesterol absorption rates between cells, and high blood-LDL cholesterol concentrations.

Having done a bit of research on optimal dieting, its pretty inconclusive.

This study shows negative consequences resulting from high fat diets for apoe4: https://www.ncbi.nlm.nih.gov/pubmed/27656136

What is the expected latency? Would this work with an FPS? Looks like its using Broadway.js?

pier to pier, in-browser reddit

SEEKING WORK - Node.js, Rails, Angular | Remote or San Francisco

LinkedIn profile: https://www.linkedin.com/in/antonlakin

Email: antonlakin (at) gmail (dot) com

I'm a full stack engineer. In the past two years i've built several MVPs for clients and just for fun. Recent in-depth projects i worked on include: online stores, interest graph ad targeting, and recommendation algorithms.

Core skills:

  * Node.js, Ruby on Rails, R
  * MYSQL, PostgreSQL, Redis, Neo4j
  * Angular, jQury, Bootstrap, D3, Three.js, core CSS and HTML
  * AWS stack, Digital Ocean, Heroku

Hobby status: drones + hardware hacking

You can email me if you'd like to discuss a project, want to brainstorm, or anything else.

Email: antonlakin (at) gmail (dot) com

SEEKING WORK - Node.js, Rails, Angular | Remote or San Francisco

LinkedIn profile: https://www.linkedin.com/in/antonlakin

Email: antonlakin (at) gmail (dot) com

I'm a full stack engineer. In the past two years i've built several MVPs for clients and just for fun, and worked on in-depth projects such as: interest graph ad targeting, analyzing twitter interest distributions, recommendation algorithms.

Core skills:

  * Node.js, Ruby on Rails, R
  * MYSQL, PostgreSQL, Redis, Neo4j
  * Angular, jQury, Bootstrap, D3, Three.js, core CSS and HTML
  * AWS stack, Digital Ocean, Heroku

Hobby status: drones + hardware hacking

You can email me if you'd like to discuss a project, want to brainstorm, or anything else.

Email: antonlakin (at) gmail (dot) com