RedditKon

Phase 2 clinical trials showed 14.7% mean weight reduction at 36 weeks in adults.

That's pretty substantial. Obviously no one knows what Phase 3 will show, but cynicism seems unwarranted at this point.

https://investor.lilly.com/news-releases/news-release-detail...

We actually have a lot of data on Ozempic and GLP-1s generally, going back to the first GLP-1 FDA approval in 2005:

• Exenatide - FDA approved in 2005

• Liraglutide / Saxenda - FDA approved in 2010

• Dulaglutide / Trulicity - FDA approved in 2014

• Semaglutide / Ozempic/Wegovy - FDA approved in 2017

• Tirzepatide / Mounjaro - FDA approved in 2022

Ozempic / Semaglutide was FDA approved in 2017, but clinical trials started in 2008. That was 16 years ago. Obviously it's always possible there are even longer term side effects we're unaware of, but generally if this class of drug caused large scale problems for kidneys, liver, etc, we'd likely know by now.

There is a great How I Built This episode about GoodReads: https://www.npr.org/2022/02/04/1078415544/goodreads-otis-and...

Out of curiosity - what are you actually doing on these walks? You're talking outloud to yourself and then editing later or what?

How is copyright / licensing working on this site? Would love to learn!

Bc none of the features are actually live yet. We keep hearing about what will be released and demos - but HN is mainly do-ers. Their launches would have 100x the impact if people could see and play with it in real time right after the announcement.

Will they just be using Microsoft's offices?

If this is happening to you in California - look into California’s Amended Automatic Renewal Law that took effect on July 1, 2022.

SEO - Google ranks those pages higher.

How are you calculating the 2 years of runway?

Last I heard they have $1B in cash on hand and are doing roughly $3B/year in revenue. Musk has reportedly gotten their annual expenses down to $3B with another $1.5B in annual debt servicing costs.

By my math that's less than a year of runway.

Why do you define United as a cadillac plan? I've only had awful experiences with them thus far.

My guess is that they don’t want to cover a $1,000/month drug to save costs that you may not incur for many years / when you’re no longer insured by them.

It only works if all the companies agree to cover it.

Ozempic is widely available in Mexico (without prescription) and Canada (with prescription). It’s also available throughout Europe.

Mounjaro is not widely available outside the US yet.

100% this. A lot of people on Mounjaro report that one of the benefits is that their internal chatter about food / cravings is silenced. For the first time, when they get hungry they’re able to stop and consider whether they should eat a salad, reduce portion size, etc.

We already have it - you can buy Semaglutide easily on the clear net as it’s relatively easy / cheap to manufacture. r/peptides has more info.

Disclaimer: I’m not advocating this - just sharing info.

Same - Mounjaro / Tirzeparide is nothing short of life changing.

A question I often get is "how effective is it?"

The SURMOUNT-1 study released in April 2022 showed 22.5% average reduction in weight for people on the highest dose of Mounjaro. For a 250 lbs person who should weigh 150 lbs (so 100 lbs of extra weight), this would result in them losing 56 lbs or 56% of their excess weight.

For context, bariatric surgery has the following success:

- Gastric Band: 35% - 45% of excess weight lost - Gastric Sleeve: 60% - 75% of excess weight lost

The fact that a once a week injection is having results similar to bariatric surgery is insane, and this is only the early innings of this shift. Lilly has another drug in the works (will likely be released in late 2025) that is reporting better results than Mounjaro.

Wild and exciting times!

I have a friend who sells Christmas ornaments on Etsy and makes ~$5k every holiday season.

It's partially because we should always act with a degree of caution and skepticism when the government can sentence people to die for betraying the government.

With a country like modern day Germany it seems easier to determine who the "good" vs "bad" guys are. But take the current situation in Iran as a counter example - there I think we'd all agree that it's decidedly less obvious that the government should have the ability to kill people who disagree.

They're unlikely to terminate entirely, but they are likely to put a temporary stay on the proceedings which is like hitting the pause button.

Is Warp just a VPN, or is that different?

It's a great thing for the environment, and a bad thing for the economy.

I love Peter Zeihan and recommend him to everyone. His commentary on the intersection of population decline and Russia's geopolitical goals from The Accidental Superpower in 2014 also turned out to be on point.

Awesome!

What % of first year salary do you charge on average?

Remarkable this site gets 22k visitors / month

12:30 PM EST - yes 4:00 PM EST - no

His mom is active on Twitter and posts a tribute to him every year: https://twitter.com/beadmomsw/status/1480974767347929098?s=2...

100 companies are responsible for 71% of global emissions. This isn't a right/left problem - both parties have let corporations get away with runaway pollution for entirely too long.

Good guy counsel