http://fightmedicine.net/uncategorized/a-medical-and-scienti...
>The effects of hormonal therapy over time, in this case testosterone deprivation and estrogen supplementation, are not completely understood. However, what is clear is that transgender individuals that underwent surgery after puberty will retain some male features, such as increased height. Male–>Female transgender patients tend to retain more muscle mass than female–>male transgender patients gain, suggesting that some gender-specific attributes remain. Whether effects such as height will prove beneficial in MMA like they do in other sports such as basketball remains to be seen. Another question is if the fighter is completely transgendered. Taking estrogens without castration will leak out testosterone that can maintain muscle mass. Furthermore, how much estrogen is being taken? If it’s not enough, then muscle strength can be closer to male levels
But this is something that can be measured and has less to do with the fact that the HRT happened after puberty.
In the male league, do some fighters get to refuse to fight others based on bone density differences? I'm thinking not, which is why this restriction seems artificial, sort of like grasping for straws to find a difference (though I'm open to being proven wrong).
> men have a biological advantage
I'm curious what biological advantage going through puberty as a male imparts that going through HRT doesn't take away.