There was Resolver One, which apparently got acquired by PythonAnywhere, which allowed Python scripted spreadsheets. It was AWESOME when I tried it, but tad too slow and no takers in the office because spreadsheets get passed around and need to be verified/rerun by people who do not know any programming. Even VBA at times.

Their OSS version is apparently still available at https://github.com/pythonanywhere/dirigible-spreadsheet (haven't tried it.)