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Re:New Letters Added to the Genetic Alphabet by gus_massa on Friday July 10, 2015 @07:08PM (#9867530)
> The problem with this RNA World hypothesis is that the reactions that current RNA can catalyze is very limited. But what if, at the origin of life, when nature could experiment, the genetic alphabet that RNA could play with was bigger, potentially leading to expanded capability?

Transfer RNA currently have a few additional bases, probably to do same things that are impossible/difficult with the standard 4 bases. See: https://en.wikipedia.org/wiki/Transfer_RNA#Structure

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