Well no one is going to get a drug approved for the FDA exclusively from the garage, but there is a reasonable amount of initial stage research that you could conceivably do from your garage. My project is to push that out to the 'xenograft' stage, which in my opinion is close to the limit, if not the limit. Full disclosure, I'm doing the chemistry in a rented chemistry lab space because I don't want to suffocate myself with chloroform.

Five arms, refers to an experiment with three dosages, a null control and a positive control.

Yes, you can outsource things, which is exactly what I'm doing (it's cheaper and more ethical), but also the model has become really good where you don't have to sack an animal for each time point. That cuts down on costs by a lot.