When .NET was first introduced, my natural language choice was VB.NET since I was coming from the classic ASP/VBScript world. Over the past 5-6 years, I've introduced more C# into my projects and now I've migrated mostly to C# + ASP.NET MVC -- in addition to Flex, Ruby/Rails. VB is still a useful language since everything compiles to the CLR anyway, but now that C# 3.5 is bringing more "dynamic" features it's more attractive to me. Plus, the syntax is so close to javascript and actionscript that it's a little easier to switch back-and-forth within the same project.But VB has served me well over the years.