I have have a notebook with internal hybrid graphics and the max number of external monitors connected. Whenever the configuration changes the utilities installed along the actual drivers (Intel and Nvidia) begin to fight for who gets to configure the layout. Monitors go on/off seemingly randomly for a few seconds. As I only use the multi monitor setup when the machine is docked, I don't care about that funny dance every morning. But there's an administrator profile on this windows machine that reproducibly locks up when in multi monitor mode.