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Re:ØMQ - The Guide by chris-hexx on Sunday May 31, 2015 @09:14PM (#9636327)
grpc is Google's flavor of RPC, with transport and semantics specified for you.

0MQ is an abstraction over raw sockets that lets you worry less about how different parts of a distributed application find and talk to each other.

There's no real direct comparison; you can implement request/reply patterns, like RPC, using 0MQ for the networking parts, but that's not all it's limited to.

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