I think seriously the intrinsic thing is that the language itself doesn't marshal (right word, not sure) anything that's particularly fat. The classic is if allocating memory require dealing with a general purpose garbage collector. If that's the case you're pretty much dead as far as systems stuff goes because now you can't predict how long anything will take to run.

And the minimal libraries usually need to be light weight as well. Or at least such that you can strip out what's not wanted. Here again garbage collection becomes an issue. If the language supports it natively then it's going to be impossible in practice to prevent the libraries from using it for something unexpected.

The last bit is escape. There are always some cases where the language doesn't have the ability to implement a critical bit of stuff and you need a way to seamlessly mess with that something. In simple you need to be able to insert a bit of arbitrary code and have it work properly.