PyCharm's debugger is awesome. [1] It really is faster then the import pdb;pdb.settrace(). (which happens to get committed sometimes). Code coverage displaying is really well implemented. Autocompletion and introspection is great. On a lot of frameworks as well. Continuously displays python linting issues and suggests fixes. Vagrant support works really good, even for remote debugging and running tests/devservers. The git implementation is quite useful, although I do fall back on command line every now and then. You can customize pycharm's interface a lot (impossible to explain in just a line or 2). If you like to edit distraction-free... there is a mode for that too. It has an internal git system. So if you screw stuff between git commits, you can revert to a previous version nonetheless (local version) There are a few ways to open files: a tree view, an "alfred"-like method and probably more.

1: https://www.jetbrains.com/pycharm/features/#debugger

Things i do not use: The internal terminal; iTerm just is a lot better. The interal ipython console. I prefer iTerm + iPython. FTP and oldschool stuff like that. Did not try the new profiling feature yet.