I've been a big fan of TFK's EIN. Unfortunately, TFK no longer maintains the project and I have not had good luck with the various EIN forks. (Anyone else having better experiences?) I still get by with the original EIN by using older versions of ipython/IPyNB. Moreover, the IPyNB technology is getting somewhat bloated with widgets and whatnot and I don't know how that will integrate with an emacs environment. Nevertheless, I still hope emacs modes similar to EIN will be forthcoming in this area. I was hoping to propose a code sprint on this topic at SciPy this year, but I won't be going to Austin, alas.