I use vertical mice exclusively. Have since probably 2006 maybe. I get no wrist pain and as I recall it took about 2 days for the vertical style form factor to feel as normal as a traditional mouse. I can go to regular mice, but I get wrist pain after a few hours or day of work. Observing your bones and your wrist twists using a normal mouse which creates strain on it. So the Evoluent Vertical Mouse 4 which isn't cheap, but has been great is my mainstay at my desk. Also the Microsoft Sculpt Ergo Mouse I have in mmy bag as a portable. Note that's Sculpt ERGO because there are a couple sculpt mice by Microsoft. And if you want really cheap, you can get the Lugu Lake vertical mouse wired for like $10 USD. That's cheap enough to try out and then if you don't like it, you could just give it away. Anker makes a couple vertical mice too on the affordable side IMO. other than Anker, Every mouse I've listed here is both one I've used for a good period of time. All are rated pretty well.