I heard from several vets I talked to that the older "giant" breeds typically have some genetic artifacts associated with increasing their size. Hip dyplasia, for example ( http://en.m.wikipedia.org/wiki/Hip_dysplasia_(canine) ).
It's amazing more breeds don't have congenital issues, given up until recently the breeding process was performed entirely without genetic testing.
[1] http://en.wikipedia.org/wiki/Aging_in_dogs