$250M might seem like a lot of money, but consider that Sheldon Adelson spent, by most estimates, upwards of $150M in campaign contributions in 2012 alone. The total spend on political influence by the gaming industry is likely to be at least an order of magnitude higher.
Furthermore, I'm equally doubtful that the NFL and the NFLPA are ok with companies making billions in profit off of the NFL's games and individual players' performances. I think that if anything kills DFS, it will be this. Sports leagues can't be associated with gambling in any way, but the teams and players involved also have to protect their brands.
Surprisingly, the NBA and MLB have an official DFS partnership - as do individual teams in both the NFL and NHL. Some individual players also have "endorsed" certain sites.
Full list of DFS partnerships: http://www.legalsportsreport.com/dfs-sponsorship-tracker/
If online poker could get enough groundswell (and, lets be honest, political backing) to receive a similar exemption, that opens to doors for a return of legalized online poker in the US.