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Re:Graduate student takes a problem-solving approach to his ... by nickysielicki on Wednesday April 01, 2015 @02:28PM (#9305727)
Not the best place to vent this but having a conversation with my mother the other day about cancer sent my mind racing. I don't think cancer will cured for a very long time.

She had watched some evening news show talking about injecting polio into cancer cells, which is some really cool research [1], but in explaining it to me it brought my attention that she held some serious misunderstandings of what cancer is. She said something like, "They would inject polio into the cells so that the body would recognize the cancer as foreign, because for some reason our bodies don't recognize cancer as foreign."

I just wonder how many people have absolutely no idea that cancer is just a damaged cell behaving naturally. It's not foreign. And with that in mind, it's kind of ridiculous to think we can do some kind of checksum of DNA at a cellular level, for every cell, for everyone. Cancer is here to stay, because it's as fundamental to life as aging and growing.

[1]: http://www.cancer.duke.edu/btc/modules/Research3/index.php?i...

Re:Graduate student takes a problem-solving approach to his ... by dekhn on Wednesday April 01, 2015 @02:43PM (#9305841)
actually, tumors are being immunosurveilled constantly, and when the immune system identifies those cells, it tries very hard to eliminate them. The immune system doesn't know or care that the cells are "foreign", just that the cells have properties, or tags that correlate with properties, that make those cells dangerous.

While I generally agree there will be no single silver bullet technology by which we "cure all cancer" in a general way with little to no side effects, I think it's not inconcievable that improving our ability to identify potentially damaging our cells will contribute a lot to keeping people cancer-free.

And while I also generally agree that cancer is inextricably intertwined with tissue growth, as an existence "proof", cancer has never been observed in naked mole rats; this observation alone is significant.

Re:Graduate student takes a problem-solving approach to his ... by jacquesm on Wednesday April 01, 2015 @02:56PM (#9305941)
The significance of the Naked Mole Rat finding is that not only does it not develop cancer, it also has a very long life-span for a rodent (decades).
Re:Graduate student takes a problem-solving approach to his ... by nickysielicki on Wednesday April 01, 2015 @02:50PM (#9305893)
Wow thanks for commenting, the bit about the naked mole rats is really interesting.

Can you explain the significance of injecting polio into cancer cells? Is it just to make the immune system definitely see that the cell is bad?

Re:Graduate student takes a problem-solving approach to his ... by jakejake on Wednesday April 01, 2015 @03:42PM (#9306268)
The theory is that cancer cells develop a protein barrier that hides their anomaly from the immune system. The polio virus is thought to damage that and the immune system thus starts to recognize them as mutated cells.

For the patients in the 60 minutes special who experienced remission (if you will), they received one injection, then it took over a year for the tumors to go away.

Re:Graduate student takes a problem-solving approach to his ... by XorNot on Wednesday April 01, 2015 @03:29PM (#9306187)
That's not the problem: the problem is "cancer" is not one illness, with one cause. It's a grouping term for literally thousands, and likely millions, of specific variations which result in unique cells which evade normal anti-cancer immunoresponses.

Even if you developed a vaccine which sensitized the immune system to one type of cancer, chances are the "type" would be limited to pretty much just the 1 person you tested it on.