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Re:Intent to Implement: Pointer Events in Chrome by acdha on Wednesday March 25, 2015 @02:55PM (#9265125)
Do you have bug reports for any of those? That RAM usage in particular suggests that the problems are more likely either specific to your application or an extension
Re:Intent to Implement: Pointer Events in Chrome by dmethvin on Wednesday March 25, 2015 @08:19PM (#9266989)
Here are some I'm aware of:

https://github.com/jquery/sizzle/issues/290

https://github.com/jashkenas/underscore/issues/2081

https://github.com/jquery/jquery/issues/2145

Webkit devs are aware of these and they have been fixed in Webkit core, but Apple doesn't provide any info about when the fixes may see the light of day.