I see far more similarities between Tufte and Lupi's work than differences (and works/talks by both of them are among the biggest influences on my approach to visualization and things I want to work on).

Both have as driving principles that people are curious and intelligent, and that visualizations should cater to that. Tufte certainly preaches "avoid unnecessary ornamentation". But he also preaches "show the data". In particular, showing individual data points, rather than aggregations, and that the purpose of a visualization is as much to provoke questions as to answer them.