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Re:OpenSSH 6.8 released by aroch on Wednesday March 18, 2015 @12:12PM (#9226508)
OSX supports PAM auth, U2F is just another kind of PAM. That's how I use my Yubikey.
Re:OpenSSH 6.8 released by feld on Wednesday March 18, 2015 @12:41PM (#9226752)
I was thinking that server side it was a PAM module, but client side it was not... for some bizarre reason.

So yeah, I suppose if your platform supports PAM this is feasible.