Yes. For example, if you choose the encrypted hard drive option when installing Debian, it'll take forever, like, hours and hours, two digit numbers of hours, because it's reading from some /dev/urandom (I presume) to initialize the drive with random data. You can skip that step though. It's way better to do it beforehand using some script that uses something other than /dev/urandom. And maybe, don't put a 1 TB hard drive in a netbook or an older machine.