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Re:Astronomers find an ancient black hole the size of 12B suns by tim333 on Thursday February 26, 2015 @03:54AM (#9111664)
You can get evidence by observing the early universe with telescopes and the like. I don't think anyone has observed the laws/constants being noticeably different although you can't really prove a negative.
Re:Astronomers find an ancient black hole the size of 12B suns by privong on Thursday February 26, 2015 @08:53AM (#9112455)
You can put limits on how much they could have changed, though. And people do this, e.g., [0], which found the proton-to-electron mass ratio has not varied by more than a relative factor of 4e-7, over the past 7.5 billion years.

[0] http://arxiv.org/abs/1412.7757