Many aspects of HGP were overhyped and much of the data remains uninterpretable. There was a strong implication that knowing the genome of humans would immediately lead to trivial improvements in health, but there wasn't actually a clear path to such improvements.

That said, it's an immensely valuable resource that pays back in many ways (it's a map which can be used for discovery science).

It's not entirely clear it drained talent and money from other projects in a way that was a net negative for science and society.