I like Clojurescript in general, but the code bloat problems and runtime speed problems still exist even with advanced optimizations. The big problem is that you have to use code that is Closure-compatible. If it isn't, there are hacks to make it work, but you end up killing the ability to remove dead code. And no matter what, you are going to end up shipping portions of the Clojure code as a runtime within the javascript runtime.

I have used cljs for non-mobile web interfaces, but the performance of Om in Phonegap on mobile hardware was terrible enough that I scrapped it for Xamarin.