I'm using Typescript + React for quite a big project, and I'm really happy with it (and even more happy with how things will work soon with this release). True, not being able to use JSX is a really big minus. Personally I'm fine with the js style "HTML.div({properties},children)" for now, and there are some people trying to get TS + JSX to work, (see https://github.com/ripieno/typescript-react-jsx and https://github.com/fdecampredon/jsx-typescript) havn't tried it myself yet, but I have good hopes this will work properly some time soon