Panama offers a super easy residence visa to citizens of 48 "friendly" countries. If your primary country of residence is Panama, you don't have to pay taxes on non-Panama-sourced income (as long as your country of citizenship doesn't tax you on your worldwide income as a non-resident). Panama corporations also don't pay taxes on non-Panama-sourced income.

From Panama City it's a 2.5 hour flight to Miami, 5 hours to New York / Toronto, about 7 hours to LA / Vegas, 10 hours to Amsterdam. Copa airlines has its base in Panama city and operates direct flights to many US and South American destinations.

A lot of people in Panama speak English so it's fairly easy to get by even if you don't know much Spanish. I found people in Panama City to be very friendly and helpful. Panama City also has great infrastructure, Internet, roads, apartments..

If you're a citizen of one of the 48 "friendly" countries you can be a legal permanent resident in Panama is a matter of months for under $5000.

And if your profession / business is global and online, you can likely break free of highway-robbery tax rates and the mind-numbing, time-wasting accounting / reporting requirements of your home country by moving to Panama.

Unfortunately for US citizens, they're still on the hook for US taxes even if non-resident in the US. But for citizens of 47 other countries, Panama is just about the #1 easiest and most practical residence option on the planet at the moment.

Search for "Panama Friendly Nations Visa".