I use the noscript tag to tell people with JS disabled that the site requires JS, end of interaction. Enable js or go away, I have more important things to do than bother with people who intentionally break their browsers. They aren't the target market and aren't worth catering to.

This is business, not academia, right and wrong are judged by profit and loss and opportunity cost, not by what is ideal given unlimited resources. Work on feature X or double my work so a few people a day who break their browsers can still use the site... one is practical, the other is not.