EDIT: Ok, I see Javascript is your thing ;), do you think doing it in JS has strong advantages over Clojure(Script)?
If you are not entrenched in the JS world, I would look into Clojure(Script). They've got a lot of really cool stuff going on.
I have significant mental investment in JS, and I work on the JS debugger for Firefox, so I feel like I need to be a heavy user of JS. Also I know so much about all the little corners of server/client JS, package management, how to deploy, etc. I don't think the return would be great enough to re-learn all of Clojure's tools.
If I were to start on certain types of apps (high-performant data modeling, or anything that requires special care about complex flows), I may look into Clojure. But honestly I'm interested in starting to write games so I'm probably going to spend mental energy learning Rust.
The more examples we can get of this the better.