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Re:Most MS Patients Who Got Stem Cell Transplants Still in R... by reasonattlm on Thursday January 08, 2015 @08:59PM (#8860315)
Yes, this is very much a treatment of killing off immune cells and sneaking in a set of replacements before the body generates its own. So that way the replacements are the ones you want, not the ones you'd otherwise get.

In autoimmunity the problem is that the immune system is misconfigured in some way - so culling existing immune cells and replacing with fresh ones stands a good chance of getting rid of the cell-based misconfiguration. That is true whether or not the misconfiguration is understood; it is a good shortcut past lack of knowledge.

This has worked for other autoimmune diseases, but is sufficiently drastic that the research community has abandoned it in favor of even marginally effective treatments for conditions where those exist. For example there were promising results in the burn-and-rebuild approach for rheumatoid arthritis a way back, but then biologics arrived offering control and less pain for some patients, and that line of research died out.

It will probably return with the advent of more targeted therapies that are not as harsh as chemotherapy, ways to selectively destroy only immune cells with specified surface chemistry. This sort of thing is underway in the cancer research community, and the technologies produced will have very broad application: safe and painless removal of immune cells, fat cells, senescent cells - anything we don't want and can be distinguished. This is a big deal but still in the works; the issue isn't destroying the cells, but rather coming up with sufficiently discriminating targeting systems.

Re:Most MS Patients Who Got Stem Cell Transplants Still in R... by DrStalker on Thursday January 08, 2015 @11:50PM (#8860829)
Sounds like the immune system version of "turn it off and back on again."
Re:Most MS Patients Who Got Stem Cell Transplants Still in R... by digi_owl on Friday January 09, 2015 @02:19AM (#8861131)
Well you are working with a self modifying system. Sometimes it may well be best to reset it back to a known good state and try again when the changes goes wonky.
Re:Most MS Patients Who Got Stem Cell Transplants Still in R... by ajuc on Friday January 09, 2015 @09:35AM (#8862349)
If only we could do perfect backups - medicine would become much simpler.
Re:Most MS Patients Who Got Stem Cell Transplants Still in R... by digi_owl on Friday January 09, 2015 @09:44AM (#8862385)
Yep. Would not mind replacing this rapidly deteriorating mass of sludge with something in metal and composites.
Re:Most MS Patients Who Got Stem Cell Transplants Still in R... by ekianjo on Friday January 09, 2015 @12:06AM (#8860862)
It has shown some efficacy as well in severe forms of RA: http://www.jrheum.org/content/31/3/482.short while it may not be conclusive yet.