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Re:Scientists are suggesting that depression is a result of ... by coldtea on Sunday January 04, 2015 @10:19PM (#8837007)
>What I'm about to say isn't to deny that inflammation might trigger or contribute to depression. In fact, anyone who thinks depressed people are just self-indulgent whiners and that there is no biochemical basis for depression are simply living in the 1950s.

Well, there's also us, who don't believe "depressed people are just self-indulgent whiners" but don't believe depression is just a "biochemical distrubance" either.

Rather, it's a byproduct of a seriously messed up world/society/personal relations landscape, that depressed individuals are more sensitive to or have felt more deeply. (This is not the same as "situational depression" -- I'm talking about the real deal, where still the causes can be numerous and not known to the sufferer at a conscious level).

(I find the whole "it's all just bio-chemistry" idea akin to reductionistic scientism. It's inherent in the prevalent attittude to not attempt to go beyond that level and question "why the inbalance", except in mechanistic terms).

Re:Scientists are suggesting that depression is a result of ... by SamReidHughes on Sunday January 04, 2015 @10:27PM (#8837034)
> Rather, it's a byproduct of a seriously messed up world/society/personal relations landscape, that depressed individuals are more sensitive to or have felt more deeply.

You can proclaim whatever you want, that don't make it true.

Re:Scientists are suggesting that depression is a result of ... by coldtea on Sunday January 04, 2015 @10:45PM (#8837104)
Sure. Doesn't make it false either.

For starters, a lot of modern "science" is hastily written papers for research grants or keeping the researcher up there, the majority of which doesn't even hold in a second examination (this was shown in several meta-reviews, including in biology/medicine, e.g.: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fj... ).

I'm not for reductionism when it comes to complex emergent phenomena like our sense of self and feelings. Especially when things like "depression" (or ADD etc) are not atemporal facts of life, but change with the decades and with interpretation.

Starting with a specific epistemology it's easy to interpret anything in a certain way. Those who've followed 19th and 20th century medicine have seen so many bullshit fads and theories that were debunked later. Even being gay was a medical issue, not many decades ago. No reason to believe "it's really different this time".

Some people treat science like some neutral agent -- as if interests, stupidity, fads and ideology don't play any role in shaping it (they have the idea that the "scientific methodology" sorts everything out). They probably just want a substitute for religion, an authoritative source of knowledge.

Re:Scientists are suggesting that depression is a result of ... by escape_goat on Monday January 05, 2015 @12:02AM (#8837378)
Well, it's true that "hastily written papers for research grants" sets a pretty low bar when it comes to the determination of useful truths about anything. But it's also true that it's a bar that your opinion doesn't even come close to clearing.

I'm glad that you're not "for" reductionism when it comes to complex emergent phenomena, but I'm not sure anyone is "for" reductionism. Some people are "for" useful abstraction.

Epistemologies... my take on them is as follows. An epistemology restricts the ways in which something can be interpreted. Periodically, this has indeed been a problem. I am not sure that it is the problem you are describing; I think perhaps you mean to say that starting with an arbitrary epistemology, its easy to interpret anything to justify prior beliefs. As soon as you formalized your epistemology, though, it would start to lock you into its logic. What sounds right would take more and more work to justify if it was not, in fact, true. That's one of the benefits of having an epistemology. That's also one of the reasons there is a history of prior false belief for you to point at. All of the "fads" you mention are beliefs that can no longer be justified within the context of a scientific method. They are not arbitrary fads; they arose out of specific, historical misapprehensions, and it is not that they cannot be individually repeated; they categorically cannot be repeated. Within the context of a specific, logically coherent method, error runs out of space. Comparing the methods and knowledge of late 20th century medicine to those of early 19th century medicine --- should you chose to --- would refute the point you are trying to make.

Meanwhile, you are responding to a person who has related his first-hand experiences and observations about a personally tragic case of clinical depression with a glib, slightly incoherent and profoundly reductionistic non-theory about the causes of his wife's illness. This is probably the product of a messed up personal relations landscape, but I will tell you that it is one to which I am extremely sensitive. Nothing is inherently false just because you pulled it out of your ass, but it is not a reliable method of producing anything you should share with anyone without making damn sure it is to the point and useful.

Re:Scientists are suggesting that depression is a result of ... by coldtea on Monday January 05, 2015 @11:31AM (#8839584)
>But it's also true that it's a bar that your opinion doesn't even come close to clearing.

Yeah, that's were traditionally people engage in discussion and evaluating each other's arguments (and even each other's opinions). Instead of expecting to settle things with some link to some research here or there, that they know even less about it that the ones that conducted it, and they have at best took a quick read of the final paper, without attempting to verify the results or anything.

Really, scientific papers, as far as their consumers in popular science are concerned, are not more than the holy scriptures of yore. Something you believe because it comes from a source of Truth.

Personally, if I'm allowed to say so, I don't believe in anything not mature enough to make it to a university syllabus. That would be 20 years and several papers by different authors at least to get to that.

>As soon as you formalized your epistemology, though, it would start to lock you into its logic. What sounds right would take more and more work to justify if it was not, in fact, true. That's one of the benefits of having an epistemology.

That's only true if epistemologies are not, like religion, flexible. But epistemologies are not some external entities, they are practiced and believed by fallible (like everyone) people.

>Meanwhile, you are responding to a person who has related his first-hand experiences and observations about a personally tragic case of clinical depression with a glib, slightly incoherent and profoundly reductionistic non-theory about the causes of his wife's illness.

Well, I'll have to disagree about the "slightly incoherent and profoundly reductionistic non-theory" part. Modern life is out of touch with the human animal and messed up, what's incoherent about it? It's an insight we celebrate in our most famous poets, writers, artists and philosophers. It's also something that can be gauged by the increase of depression incidents in particular countries and particular decades.

And who told you I, and people close to me, haven't experience depression? It's not like that persons first hand experiences are the be all end all, and it's not like first hand experience mean that much in any case.

There are all kinds of people with a wrong opinion (could be me, for example, as I'm saying this) that had "first had experiences" that got them to that opinion.

Re:Scientists are suggesting that depression is a result of ... by javert on Sunday January 04, 2015 @11:34PM (#8837301)
> They probably just want a substitute for religion, an authoritative source of knowledge.

Going on a complete tangent here. And I'm not disagreeing with anything you said.

The substitute for religion is philosophy, not science.

Re:Scientists are suggesting that depression is a result of ... by randallsquared on Sunday January 04, 2015 @11:51PM (#8837345)
Philosophy and science aren't opposed. Philosophy is conjecture about fields in which we don't know enough to have a science, yet. This is not a dig at philosophy; it's important to keep searching for answers so that we do get enough evidence to build a science.
Re:Scientists are suggesting that depression is a result of ... by javert on Tuesday January 06, 2015 @02:33AM (#8843280)
I don't agree with that at all. Philosophy should and can be held to the same rigor as science, i.e., objectivity.
Re:Scientists are suggesting that depression is a result of ... by randallsquared on Tuesday January 06, 2015 @10:17AM (#8844669)
I think there are at least some philosophical topics which are non-objective by nature. Consider whether to be a solipsist. ;) More seriously, if you don't believe in an objective morality, then moral philosophy is a subject which qualifies.
Re:Scientists are suggesting that depression is a result of ... by javert on Thursday January 08, 2015 @08:00PM (#8860111)
Something that is non-objective by nature is a matter of faith, not philosophy.

I do believe in objective morality. Morality is simply the study of what we should do. What should we do? That question is perfectly open to scientific enquiry.

If Hume was right---that the question cannot be answered scientifically---then that's the end of moral philosophy and the beginning, perhpas, of morality based in faith. but I do not agree with Hume.

Re:Scientists are suggesting that depression is a result of ... by garrettgrimsley on Sunday January 04, 2015 @11:47PM (#8837332)
>The substitute for religion is philosophy, not science.

Philosophy has not offered me the easy, yet wholly unsatisfying, answers that my baptist upbringing did. I wouldn't say that it is the best substitute for religion.

Re:Scientists are suggesting that depression is a result of ... by SamReidHughes on Sunday January 04, 2015 @11:37PM (#8837307)
Blathering about science and medicine still doesn't make your made-up proclamation about the cause of depression any less made-up.
Re:Scientists are suggesting that depression is a result of ... by gorklin on Monday January 05, 2015 @12:41AM (#8837487)
Way to back your claim with reason and evidence, SamReidHughes. You think coldtea is blathering? Prove it.

There's a huge difference between "blathering", i.e. incoherence, and disagreement. If you truly find coldtea's comment incoherent, you may have an issue with reading comprehension.

Re:Scientists are suggesting that depression is a result of ... by Alex3917 on Sunday January 04, 2015 @11:55PM (#8837359)
> Rather, it's a byproduct of a seriously messed up world/society/personal relations landscape, that depressed individuals are more sensitive to or have felt more deeply.

- Even if this were true, that doesn't preclude depression from causing biochemical changes (e.g. inflammation).

- Saying this is the only cause of depression doesn't make a lot of sense because it doesn't account for, say, post-surgical or post-viral depression.

Re:Scientists are suggesting that depression is a result of ... by throwawaybcporn on Monday January 05, 2015 @02:21PM (#8840569)
> Rather, it's a byproduct of a seriously messed up world/society/personal relations landscape, that depressed individuals are more sensitive to or have felt more deeply.

As I went to bed last night, I found myself thinking about this comment.

A couple of years ago, I was working at a well-known tech company and doing very well. My boss was a legitimate, clinical psychopath, but I made the most of it, working hard, coming in on weekends and snow days, etc. For my effort and talent, I received a raise and super-secret "restricted stock units we only give to the people we want to keep" after only a few months. My final performance review was glowing.

Having had enough of my boss and feeling that I'd built up enough runway to make a jump, I asked my boss's boss for a transfer to a different manager. The request was received positively and as it was in process, my immediate boss found out (probably from another manager asking about me) and summarily fired me. The act of cleaning out my desk and saying an awkward goodbye to people in the office is as clear to me as if it happened yesterday.

Because he had neglected to consult with his management chain about it, he was also out the door as soon as the threat of a lawsuit from me had passed a few months later. (If you're wondering, I did make some empty legal threats after the fact, which is why I couldn't go back. In retrospect, I probably could have returned if I'd kept my cool. I regret this mistake more than anything I did beforehand, without a doubt.)

Since then, I've suffered from PTSD, extreme anxiety and secondary depression, have been almost completely unemployed and largely withdrew from normal society. I don't have many friends anymore, don't date, don't go out... I basically just keep to myself, code, and play video games. Interacting with people didn't work out so well, so I guess, subconsciously and maybe a little consciously, I just decided not to deal with them anymore.

Getting back to your comment, @coldtea, I've often wondered which is true: Do I (a) have a "chemical imbalance" caused by unmet life expectations that causes me to be anxious and depressed or am I (b) depressed because the veil that had theretofore kept me from seeing/understanding the true shitty nature of the world was lifted?

I find my mind frequently drifting into "wow, everything is fucked up" territory. And there's plenty of fuel to keep the engine running. Everything from terrorism to wealth inequality to labor destruction to race issues to dictatorships to privacy loss to partisan gridlock in Washington... the world is absolutely and in a thousand different ways, flagrantly unfair. Then I get even further depressed about feeling depressed when I compare my relatively cushy life to that of, say, a Palestinian or Ugandan.

Wealth (and as a corollary, race) inequality is the one that gets me the most. Technology is advancing to post-scarcity -- the point where there are enough resources on this globe that everyone should be able to make it by with minimal (or even zero) effort.

But that's not what's happening. Keynes was wrong about the 15-hour work week of the future. Instead, we've gotten a bi-modal distribution of the disgustingly wealthy and growing numbers (in the US) of the destitute who have to work more hours at degrading jobs just to get by. Most people still have to work at things they do not enjoy, an artificial construct held in place by the powers that be. In this 21st century, there is enough to go around, it's just not distributed properly.

To be clear, I don't mind working and have a long history of hopefully-interesting side-projects (which I'd hoped would break me out of the must-work 99% group). What I do mind is working for "them" because I need to make X dollars to live in the world "they" have constructed. Even when I did work for "them" I didn't hate it. But now... it's harder to accept.

What pill is going to make me forget these harsh realities of the world? What pill is going to make me say "Oh sure, I'll get a wife and have some kids, even though they'll be relegated to psuedo-slavery just like I am." None.

So I think what you said (which I quoted above) is dead-right. Because of an event in my life, my eyes were opened to the real unfairness of the world.

And that's the real reason I struggle with depression -- my understanding of the world improved.