They absolutely do. For example, police in Seattle explicitly made marijuana enforcement the lowest possible priority years before Washington legalized it. It was a common sight to see policemen standing right next to people openly smoking pot on the street and completely ignoring them.
The police actually have a huge amount of leeway, and it can be a big problem. They often decide who to prosecute and who to ignore, and their decisions are often driven by race, revenue concerns, or other issues that have little to do with justice.
[1] http://www.seattlepi.com/local/article/Two-years-later-littl...
If you disagree with the morality of a law, fine - but your assertion that enforcing drug laws is as immoral as enforcing slavery laws is debatable
If you want a legal precedent, the Nuremberg trials somewhat settled that question.