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A comment on Adblock Plus is probably the reason Firefox and Chrome are such memory hogs. Parent comment
Use the context menu. There is an option to "hide" (delete) the ad there.
Another option is this bookmarklet (only works if the element that should be deleted isn't in an iframe):
javascript:(function(){var e=document.body.style.cursor;document.body.style.cursor="crosshair";var t=document.createElement("div");var n="border:1px solid #3280FF;background-color:rgba(50,128,255,0.5);position:absolute;z-index:2147483647;display:none;";var r="pointer-events:none;";var i="transition:width 60ms,height 60ms,left 60ms,top 60ms;";n+=r+"-webkit-"+r+"-moz-"+r;n+=i+"-webkit-"+i+"-moz-"+i;t.setAttribute("style",n);document.body.appendChild(t);var s=null;var o=function(e){var n=e.target;if(n!==s&&n.parentNode){var r=n.getBoundingClientRect();var i=document.documentElement;var o=document.body;var u=i.clientTop||o.clientTop||0;var a=i.clientLeft||o.clientLeft||0;var f=window.pageYOffset||i.scrollTop||o.scrollTop;var l=window.pageXOffset||i.scrollLeft||o.scrollLeft;var c=l-a+r.left-1;var h=f-u+r.top-1;t.style.display="block";t.style.left=c+"px";t.style.top=h+"px";t.style.width=r.width+"px";t.style.height=r.height+"px";s=n}};var u=function(n){document.body.style.cursor=e;if(n.target.parentNode)n.target.parentNode.removeChild(n.target);if(t.parentNode)t.parentNode.removeChild(t);window.removeEventListener("click",u,false);window.removeEventListener("mouseover",o,false);n.stopPropagation();n.preventDefault()};window.addEventListener("mouseover",o,false);window.addEventListener("click",u,false)})();void(0)
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Use the context menu. There is an option to "hide" (delete) the ad there.
Another option is this bookmarklet (only works if the element that should be deleted isn't in an iframe):