There are too wide spaces between text and metadata, too lwo contrasts between light shades of grey and a disrupted context for some elements (see My Profile and Search).
#fail
Where I work we run a website targeted to everyone - mom, pop, grandpa, college dude, etc. Suffice to say, our minimum resolution and colour depth requirements are really low. Experience has proven this to be far wiser than Web 2.0-ing everything and assuming people have screen real estate.
The design here won't work on low resolution displays. The news feed would - but that's only because their design wastes a truckload of space down the middle. Their photo viewer, and calendar will break on any low-resolution screen.
Can it be fixed? Sure, but I have a feeling the more you "fix" their design, the closer you're going to get to where Facebook already is today ;)
Also, it's bland and ugly as fucking sin.
This is an example of the worst kind of design, where the designer has gone through a self-absorbed process of moving around and resizing elements that Facebook created through years of experience with real users.