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Re:Facebook Launches Flow, Static Type Checker for JavaScript by judah on Tuesday November 18, 2014 @01:46PM (#8625504)
One major difference is the null checking. From what it looks like, they've added an additional type, "maybe", that represents a possibly-null object.

TypeScript doesn't have that concept, although it's been suggested by the community more than once.

Re:Facebook Launches Flow, Static Type Checker for JavaScript by inglor on Tuesday November 18, 2014 @01:57PM (#8625599)
Here is some interesting discussion on that aspect of the typesystem: https://github.com/Microsoft/TypeScript/issues/14 It also discusses Flow from 2 months ago (from a now removed video)