I tried a lot of the popular Backup solutions (like Acronis and others I don't remember now), but none of them really worked for me.

I'm using HardlinkBackup for incremental, local USB backups (periodically creates a new folder with a full snapshot of the entire disk but de-duplicates across snapshots with NTFS hard links).

http://www.lupinho.net/hardlinkbackup/

For Cloud Backups I'm a happy Backblaze customer.