Forcing a MITM to compromise DNSSEC before they can read the cleartext is a worthwhile barrier to add IMO.
It would hurt mail reachability, but are there any useful numbers as to how badly?
Additionally, it seems as though a solution analogous to HSTS might be better than involving DNSSEC. An SMTP server could advertise that it should be connected to only over TLS - information that could be cached by the sending system.
There is still a MITM problem on 1st connection, but that's an issue for many systems and avoids trusting DNSSEC.
The good thing about involving DNSSEC+DANE is that, even the first time an SMTP server connects to another, it knows that it must use TLS and must expect a particular certificate. With HSTS you don't get that protection on the first connection.
I guess DANE (with or without DNSSEC) could also be used to cover the first connection, but I guess I'd prefer a world where the previous connection was used as the primary point of trust (the HSTS+TACK approach) rather than the "trusted root" (DNSSEC or CA).
Surely if you're worried about state actors, this is no help?