Although they are my primary languages :

I dislike dealing with setting up specific python instances. I hate the differing versions and the specific libraries of software that each version breaks vice-versa. Virtual environments serve to make things easier if you have a singular routine, but usually add unneeded complexity. I have felt that the split between the pythons was a detriment ever since it was announced, and it has lead to more work for me overall. (I understand the reasons, before anyone tries to convince me to change my mind)

I hate setting up my common lisp environment, but that's thankfully pretty rare.