My main gripe with significant white space is that it forces a specific level of formatting that is generally less attractive and readable then what I would otherwise use.

Please elaborate. Usually, significant whitespace only forces code at the same nesting level to have the same indentation, it doesn't specify what that indentation should be.

I dislike significant whitespaces because when there's a lot of code that has multiple nesting levels it becomes a bit hard to follow. I like it when my code has a beginning and and ending token ({ and } in JS/C/C++ or `begin` and `end` in Ruby). Whilst writing CS I found myself writing `# end` a lot.

Also, not to mention (maybe my editor lacks this feature) I like using ^M to jump from end to beginning braces of blocks, and I can't seem to do that in CS.

However, all of these arguments just boil down to "this is my personal preference"

My main gripe is that it makes moving code around painful and it introduces bugs that are difficult to spot. Literally.