So you need tons of users per sub, with very high level expertise; you need dedicated moderators with expertise in the category so they grasp what's what. And you need some way to bring all of these people in just to get the ball rolling (Stack did it by knocking over one category first of course).
Even Stack Exchange has failed to translate its very successful core site to a vast range of topics. If you look at where they've succeeded in a big way, it's exclusively tech-heavy or otherwise topics that geeks like.
Wikipedia is a great guide of things to avoid.
Take signing up for an account: the software has some control over what username you can create. Then there is some level of admin on top. So, as well as the software limits there is the username policy.
http://en.m.wikipedia.org/wiki/Wikipedia:Username_policy
That page has nice advice about what to do with bad usernames - starting with do nothing.
There are two templates for bad usernames (templates are generally a bad idea) -- {{subst:uw-username}} or {{subst:uw-coi-username}}
Then there is a Request for Comments http://en.m.wikipedia.org/wiki/Wikipedia:RFC/N
And then there's an admin noticeboard http://en.m.wikipedia.org/wiki/Wikipedia:Usernames_for_admin...
But the noticeboard has two parts - a holding pen and the main board.
The RFC/U is the problematic part. Children rapidly post all possibly risky usernames as part of their gamified run to adminship.
You kind of expect editing topics like Palestine or Ukraine to be risky. You really don't expect simple uncontroversial punctuation gnoming to be horrible but it can be a really nasty toxic experience.
"I'm switching from this programming language to that programming language; what are the important gotchas?"
I think SE is awesome in spite of its rules, not because of them. The whole "discussion is bad mmkay" thing seems to be cargo-culted by the staff of these sites despite many examples to the contrary.
This has actually been my #1 appalling thing about Quora. The questions being asked on it are so often such a low quality that I worry about if I'm getting in to some sort of intellectual ghetto. Consequently, I rarely want Quora to tell anybody that I was on that website. I have also developed perception that people very active on Quora have fairly low bar (note that there are many tech celebrities on it but they are usually one-offs).
Examples from current Quora frontpage:
"How do people who have been affected by "Bendgate" feel about it?"
"Why am I so scared to ask for help?"
It's odd that nothing fills this gap. Slant.co comes close, but is built around "what" rather than "why" or "how" -- useful in its own right, but not the same.
I wonder if the problem is simply that Yahoo! Questions, Ask.com and Quora are all just too well-known and nobody wants to take them on, despite how terrible they are? Considering the celebrated audacity of startup culture I'd honestly be surprised if this is the case, but on the other hand I'm not finding a lot of other compelling explanations.
I suppose one other possibility is that aforementioned sites have soured the public on the genre to the point that when someone says, "It's kind of like Yahoo Questions or Ask.com," the immediate response is "Ick."