To follow up on this, a lot of the overhead from reverse-mode AD can be avoided by flattening out the expression graphs and compiling specialized functions (at runtime). A number of the JuliaDiff packages support this approach. This is not a new idea, but Julia's hooks to LLVM make this surprisingly easy to do.
You can make use of AD for more than just playing around too, esp. for optimization (JuliaOpt [4]): Optim.jl will use them to calculate exact derivatives if you don't provide them, and JuMP.jl will use them to calculate the sparse Jacobian and Hessian matrix for a nonlinearly constrained optimization problem (which can be used by, e.g. Ipopt.jl)
[1]: http://en.wikipedia.org/wiki/Automatic_differentiation
[2]: http://julialang.org/
[3]: http://juliadiff.org/
[4]: http://juliaopt.org/