None that I know of - As a novice python programmer, I just try and use comprehensions for everything so my eyes get used to the pattern.

The set function is somewhat faster.

  a=[]
  for x in range(10000):
      a.append(randint(1,2000))

  %timeit b=set(a)
  1000 loops, best of 3: 373 µs per loop

  %timeit b={x for x in a}
  1000 loops, best of 3: 542 µs per loop

style

While comprehensions are definitely standard Python, I would argue that if you're not actually changing any value (as is the case here, then just `set(a)`, being much simpler, is more Pythonic.