Deeply nested I'd usually agree, but if you end up with deeply nested comprehensions as a result, in either case, you're probably better off with a little bit of restructuring/splitting things more functions to at least make the nesting cleaner to read.

However, I think he was referring to if the conditionals/additional modifications needed to build your list get a bit excessive, so you'd have a like... [dostuffto(A) for A in alsodostuffto(LIST) if conditional(A)] (but with more complex operations at each step).

Granted at that point you can argue that you should do just as my example shows and put the "dostuffto" into more encapsulated functions, but sometimes that doesn't seem like the right choice.