In addition to color, designers should check to see if their sites break when minimum font size is set in browsers. I like to browse at 18 pt min, and many sites are awful. Mostly because they insist on fixed widths for many sub-elements on the screen.

HN is one site that works quite well at 18 pt min. I don't know about color issues, but HN seems simple enough that it's probably not a problem.

HN also works great w/o JavaScript.