Sage is a free open-source mathematics software system licensed under the GPL. It builds on top of many existing open-source packages: NumPy, SciPy, matplotlib, Sympy, Maxima, GAP, FLINT, R and many more.
Access their combined power through a common, Python-based language or directly via interfaces or wrappers.
Mission: Creating a viable free open source alternative to Magma, Maple, Mathematica and Matlab.
There are bits of that concept that come from elsewhere, so it's not 100% novel coming from nowhere. E.g. older computer-algebra systems, Matlab, etc., all have bits of the ideas that this particular class of mathematics+data systems is converging on. But prior to the current wave of open-source stuff, I think Mathematica had the best example of integrating it all into a usable system. It might still be the most polished and integrated one out there; parts of Sage still very much feel like libraries with different conceptual/interaction models, glued together with a thin layer of Python glue. Though Sage does have the advantage of being able to add functionality at a more rapid pace, and I assume the integration will get more seamless in the future.